IKKγ NBD Inhibitory Peptide ( —— )

产品货号. M30314 CAS No. 372146-18-4

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HPLC

MSDS

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产品名称

IKKγ NBD Inhibitory Peptide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
产品描述

A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
体外实验

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体内实验

Animal Model:Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)Dosage:40 μg/4 μL Administration:Intracerebroventricular injection; 2 h before MCAO induction Result:Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult.
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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

372146-18-4
分子量

3693.3
分子式

C170H259N49O42S1
纯度

>98% (HPLC)
溶解度

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SMILES

——
化学全称

Sequence:{Asp}{Arg}{Gln}{Ile}{Lys}{Ile}{Trp}{Phe}{Gln}{Asn}{Arg}{Arg}{Met}{Lys}{Trp}{Lys}{Lys}{Thr}{Ala}{Leu}{Asp}{Trp}{Ser}{Trp}{Leu}{Gln}{Thr}{Glu}

Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663.

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